Demographic of online dating users

Results Over a median follow-up of 5.71 years (IQR 5.11–6.37), PPI use was associated with increased risk of death compared with H2 blockers use (HR 1.25, CI 1.23 to 1.28).Risk of death associated with PPI use was higher in analyses adjusted for high-dimensional propensity score (HR 1.16, CI 1.13 to 1.18), in two-stage residual inclusion estimation (HR 1.21, CI 1.16 to 1.26) and in 1:1 time-dependent propensity score-matched cohort (HR 1.34, CI 1.29 to 1.39).

We therefore used the Department of Veterans Affairs national databases to build a longitudinal cohort of incident users of acid suppression therapy, including PPI and histamine H2 receptor antagonists (H2 blockers), to examine the association between PPI use and risk of all-cause mortality and to determine whether risk of death is increased with prolonged duration of use.

Using administrative data from the US Department of Veterans Affairs, we identified patients who received an outpatient H2 blockers or PPI prescription between 1 October 2006 and 30 September 2008 (n=1 762 908).

In order to select new users of acid suppression therapy (incident user design), we excluded 1 356 948 patients who received any outpatient H2 blockers or PPI prescriptions between 1 October 1998 and 30 September 2006.

The VA Vital Status and Beneficiary Identification Records Locator Subsystem files provided demographic characteristics and death. Once cohort participants received PPI prescription, they were considered with the effect of PPI until the end of follow-up.

Medications that contain esomeprazole, lansoprazole, omeprazole, pantoprazole or rabeprazole were counted as PPI.

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Patients who received H2 blockers as their first acid suppression therapy (n=73 335) served as the reference group before they received any PPI prescription (see online supplementary figure 1).

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